|
KMID : 0614620120590060401
|
|
Korean Journal of Gastroenterology
2012 Volume.59 No. 6 p.401 ~ p.406
|
|
|
Comparison of Rifabutin- and Levofloxacin-based Third-line Rescue Therapies for Helicobacter pylori
|
|
Jeong Myung-Ho
Chung Jun-Won
Lee Sang-Jin
Ha Min-Su
Jeong Seok-Hoo
Na Sun-Young
Na Byung-Soo
Park Sung-Keun
Kim Yoon-Jae
Kwon Kwang-An
Ko Kwang-Il
Jo Yun-Jeong
Hahm Ki-Baik
Jung Hwoon-Yong
|
|
|
Abstract
|
|
|
Background/Aims: There is increasing need for third-line therapy of Helicobacter pylori due to increasing level of antibiotics resistance. The aim of this study was to compare rifabutin and levofloxacin rescue regimens in patients with first- and second-line Helicobacter pylori eradication failures.
Methods: Patients, in whom a first treatment with proton pump inhibitor-clarithromycin-amoxicillin and a second trial with proton pump inhibitor-bismuth-tetracycline-metronidazole had failed, received treatment with either rifabutin or levofloxacin, plus amoxicillin (1 g twice daily) and standard dose proton pump inhibitor. Eradication rates were confirmed with 13C-urea breath test or rapid urease test 4 weeks after the cessation of therapy.
Results: Eradication rates were 71.4% in the rifabutin group, and 57.1% in the levofloxacin group, respectively. Although there was no significant difference in Helicobacter pylori eradication rates between two groups (p=0.656), rifabutin based regimen showed relatively higher eradication rate.
Conclusions: Helicobacter pylori eradication rates of rifabutin- or levofloxacin-based triple therapy could not achieve enough eradication rate. Further studies would be needed on combination of levofloxacin and rifabutin-based regimen or culture based treatment. (Korean J Gastroenterol 2012;59:401-406)
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Rifabutin, Levofloxacin, Third line, Salvage therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|